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Article

The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation

1 Jan 2015

Abstract excerpt

Endotoxin tolerance in macrophages is a key regulatory mechanism to limit the innate immune response to infection or injury. Long considered a state of unresponsiveness to Toll-like receptor activation, tolerance is now recognized as a state of altered responsiveness to infection or injury. Endotoxin tolerance leads to a shift away from a pro-inflammatory response toward a response with key anti-inflammatory and...

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PMID: 26757393
DOI: 10.1615/critrevimmunol.2015015495

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