Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.

Genes and immunity - 1 Dec 2004

Gordon A C, Lagan A L, Aganna E, Cheung L, Peters C J, McDermott M F, Millo J L, Welsh K I, Holloway P, Hitman G A, Piper R D, Garrard C S, Hinds C J

Abstract excerpt

Tumour necrosis factor (TNF) is an important pro-inflammatory cytokine produced in sepsis. Studies examining the association of individual TNF single nucleotide polymorphisms with sepsis have produced conflicting results. This study investigated whether common polymorphisms of the TNF locus and the two receptor genes, TNFRSF1A and TNFRSF1B, influence circulating levels of encoded proteins, and whether individual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Australia
Share to England

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Tumor Necrosis Factor

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Sepsis

Share to Shock, Septic

Share to White People

Source

Identifiers

PMID: 15526005
DOI: 10.1038/sj.gene.6364136

Genes

TNF
TNFRSF1A
TNFRSF1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.PMID 15526005Read ↗

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.Semantic proximity Read ↗

Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.Semantic proximity Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock.Semantic proximity Read ↗

Does tumor necrosis factor alpha promoter -308 A/G polymorphism has any role in the susceptibility to sepsis and sepsis risk? A meta-analysis.Semantic proximity Read ↗

Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis.Semantic proximity Read ↗

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness.Semantic proximity Read ↗

Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor.Semantic proximity Read ↗

Role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality: A Meta-AnalysisSemantic proximity Read ↗

The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.Semantic proximity Read ↗

Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis.Semantic proximity Read ↗

Association of TNF-α-308 (G >A) (rs1800629) Gene Polymorphism with Adverse Outcomes of Sepsis in Critically Ill Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.