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Article

Association of thymidylate synthase gene polymorphisms with stavudine triphosphate intracellular levels and lipodystrophy.

Antimicrobial agents and chemotherapy - 1 Apr 2011

Domingo Pere, Cabeza M Carmen, Pruvost Alain, Torres Ferran, Salazar Juliana, del Mar Gutierrez M, Mateo M Gracia, Fontanet Angels, Fernandez Irene, Domingo Joan C, Villarroya Francesc, Vidal Francesc, Baiget Montserrat

Abstract excerpt

The antiviral activity and toxicity of stavudine (d4T) depend on its triphosphate metabolite, stavudine triphosphate (d4T-TP). Therefore, modifications in intracellular levels of d4T-TP may change the toxicity profile of stavudine. d4T-TP intracellular levels in peripheral blood mononuclear cells were determined with a prominence liquid chromatograph connected to a triple-quadruple mass spectrometer....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21282454
DOI: 10.1128/AAC.01589-10
PMCID: PMC3067160

Genes

CCND1
DHFR
MTHFR
RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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