Article
A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations.
Human genetics - 1 Apr 2005
Kealey Carmel, Brown Karen S, Woodside Jayne V, Young Ian, Murray Liam, Boreham Colin A, McNulty Helene, Strain J J, McPartlin Joseph, Scott John M, Whitehead Alexander S
Abstract excerpt
Substantial evidence suggests that a low folate/high homocysteine phenotype is pathogenic. We analyzed the impact of the thymidylate synthase (TYMS) 3'UTR ins/del polymorphism on folate and homocysteine levels and assessed the relationship between the TYMS 3'UTR ins/del polymorphism and key genetic and lifestyle variables. Among non-smokers only, the TYMS 3'UTR ins/del polymorphism was significantly associated...
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