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Article

Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry.

Clinical chemistry and laboratory medicine - 1 Jan 2006

Smith Desirée E C, Kok Robert M, Teerlink Tom, Jakobs Cornelis, Smulders Yvo M

Abstract excerpt

BACKGROUND: Given the role of folate in many disorders, intracellular distribution of folate vitamers is of potential clinical importance. In particular, accumulation of non-methyltetrahydrofolates due to altered partitioning of folate metabolism at the level of methylenetetrahydrofolate is of interest. METHODS: We describe a positive-electrospray liquid chromatography tandem mass spectrometry (LC-MS/MS) method...

Topics

Chromatography, High Pressure Liquid
Erythrocytes
Folic Acid
Genotype
Humans
Mass Spectrometry
Methods
Methylenetetrahydrofolate Reductase (NADPH2)
Reproducibility of Results
Tetrahydrofolates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16599840
DOI: 10.1515/CCLM.2006.085

Genes

MTHFR

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