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Article

Pharmacogenetic determinants of tenofovir diphosphate and lamivudine triphosphate concentrations in people with HIV/HBV coinfection.

Antimicrobial agents and chemotherapy - 4 Sept 2024

Bae Jihyun, Tantawy Marwa, Gong Yan, Langaee Taimour, Lartey Margaret, Ganu Vincent, Tachi Kenneth, Ojewale Oluwayemisi, Obo-Akwa Adjoa, Boamah Isaac, Bushman Lane R, Ellison Lucas, Yang Hongmei, Anderson Peter L, Kwara Awewura

Abstract excerpt

The nucleos(t)ide analogs require phosphorylation to the pharmacologically active anabolites in cells. We investigated the hypothesis that single-nucleotide polymorphisms (SNPs) in genes that encode transporters and phosphodiesterase (PDE) enzymes involved in tenofovir (TFV), disoproxil fumarate (TDF), and lamivudine (3TC) disposition will be associated with concentrations of their phosphate anabolites and...

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Identifiers

PMID: 39078131
DOI: 10.1128/aac.00549-24
PMCID: PMC11373203

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