Article

Thymidylate Synthase Gene in Pharmacogenetics.

2004-06-01

Abstract excerpt

Thymidylate synthase (TS) is the target for widely used anticancer agent 5-fluorouracil (5-FU) and a number of other TS inhibitors are now either in clinical use or under development. The TS gene has a variable number of tandem repeat (VNTR) sequence, mainly 2 repeats (2R) and 3 repeats (3R), which are promising candidates for prediction of the effectiveness and adverse drug reactions of TS inhibitors. It has been...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a15d06c-8f59-5a9d-be78-2c727c8a0ac2
DOI: 10.2174/1570160043377628

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thymidylate Synthase Gene in Pharmacogenetics.DOI 10.2174/1570160043377628Read

Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer.Semantic proximity Read

<i>Thymidylate synthase</i>gene variations: predictive and prognostic markersSemantic proximity Read

Update on pharmacogenetics in cancer chemotherapy.Semantic proximity Read

Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.Semantic proximity Read

Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells.Semantic proximity Read

Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer.Semantic proximity Read

Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients.Semantic proximity Read

Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene.Semantic proximity Read

An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens.Semantic proximity Read

Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal CancerSemantic proximity Read

Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients.Semantic proximity Read

Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis.Semantic proximity Read