Article
Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM - 1 Aug 2008
Huang Yuehua, Khartulyari Stefanie, Morales Megan E, Stanislawska-Sachadyn Anna, Von Feldt Joan M, Whitehead Alexander S, Blair Ian A
Abstract excerpt
Red blood cell (RBC) folate levels are established at the time of erythropoiesis and therefore provide a surrogate biomarker for the average folate status of an individual over the preceding four months. Folates are present as folylpolyglutamates, highly polar molecules that cannot be secreted from the RBCs, and must be converted into their monoglutamate forms prior to analysis. This was accomplished using an...
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