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Article

Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity.

Molecular genetics and metabolism - 1 Apr 2011

Ho Vikki, Massey Thomas E, King Will D

Abstract excerpt

BACKGROUND: DNA methylation plays a critical role in gene regulation and has been implicated in the etiology of chronic disease including atherosclerosis, neural degeneration and cancer. One-carbon metabolism serves two critically important functions: one concerning the production of purines and thymidine for DNA synthesis and the other related to the provision of methyl groups through the metabolism of...

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Identifiers

PMID: 21269855
DOI: 10.1016/j.ymgme.2010.12.015

Genes

MTHFR

Variants

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