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Article

Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients.

Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2008

Kiser Jennifer J, Aquilante Christina L, Anderson Peter L, King Tracy M, Carten Monica L, Fletcher Courtney V

Abstract excerpt

BACKGROUND: Nucleos(t)ide reverse transcriptase inhibitors (NRTIs), such as tenofovir, require intracellular phosphorylation for pharmacologic activity. Drug transporters may contribute to the intracellular disposition of NRTIs. OBJECTIVE: We characterized intracellular tenofovir diphosphate (TFV-DP) concentrations in HIV-infected patients (n = 30), and investigated associations between TFV-DP concentrations and...

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Source

Identifiers

PMID: 18398970
DOI: 10.1097/qai.0b013e31815e7478

Genes

ABCC4
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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