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Marked aneuploidy and loss of multiple chromosomes are common in autosomal mutants isolated from normal mouse kidney epithelium.

Genes, chromosomes & cancer - 1 Apr 2011

Dan Cristian, Grygoryev Dmytro, Sandfort Kelly, Connolly Marissa, Cross Brittany, Lasarev Michael, Kronenberg Amy, Turker Mitchell S

Abstract excerpt

Marked aneuploidy and loss of multiple chromosomes are hallmarks of cancer, but whether these events are only present in malignant cells is not known. In prior work, we showed that approximately half of spontaneous autosomal mutants isolated directly from normal kidney epithelium arose from loss of a marker chromosome 8 containing the wild type Aprt gene. Chromosome loss was detected by loss of heterozygosity...

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Identifiers

PMID: 21254298
DOI: 10.1002/gcc.20849
PMCID: PMC3079405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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