Article
Autosomal mutations in mouse kidney epithelial cells exposed to high-energy protons in vivo or in culture.
Radiation research - 1 May 2013
Turker Mitchell S, Grygoryev Dmytro, Dan Cristian, Eckelmann Bradley, Lasarev Michael, Gauny Stacey, Kwoh Ely, Kronenberg Amy
Abstract excerpt
Proton exposure induces mutations and cancer, which are presumably linked. Because protons are abundant in the space environment and significant uncertainties exist for the effects of space travel on human health, the purpose of this study was to identify the types of mutations induced by exposure of mammalian cells to 4-5 Gy of 1 GeV protons. We used an assay that selects for mutations affecting the chromosome...
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