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Article

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999

Shao C, Deng L, Henegariu O, Liang L, Raikwar N, Sahota A, Stambrook P J, Tischfield J A

Abstract excerpt

Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study in vivo loss of heterozygosity (LOH) in normal fibroblasts. Somatic cell variants that exhibited functional loss of the wild-type Aprt in vivo were recovered as APRT-deficient cell colonies after culturing in selection medium containing 2, 6-diaminopurine (DAP), an adenine analog that is toxic only to cells with APRT...

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Source

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Identifiers

PMID: 10430925
DOI: 10.1073/pnas.96.16.9230
PMCID: PMC17762

Genes

DAP
APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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