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Article

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.

Nucleic acids research - 1 Nov 1998

Van Sloun P P, Wijnhoven S W, Kool H J, Slater R, Weeda G, van Zeeland A A, Lohman P H, Vrieling H

Abstract excerpt

A mouse model was generated to investigate loss of heterozygosity (LOH) events in somatic cells. The adenine phosphoribosyltransferase ( Aprt ) gene was disrupted in embryonic stem cells using a conventional gene targeting approach and subsequently Aprt hetero-zygous and homozygous mice were derived. Aprt homozygous deficient animals were viable though the mendelian inheritance pattern was skewed. On average...

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Identifiers

PMID: 9776749
DOI: 10.1093/nar/26.21.4888
PMCID: PMC147942

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