Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.

doi:10.1093/nar/26.21.4888

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Article

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.

Nucleic acids research - 1 Nov 1998

Van Sloun P P, Wijnhoven S W, Kool H J, Slater R, Weeda G, van Zeeland A A, Lohman P H, Vrieling H

Abstract excerpt

A mouse model was generated to investigate loss of heterozygosity (LOH) events in somatic cells. The adenine phosphoribosyltransferase ( Aprt ) gene was disrupted in embryonic stem cells using a conventional gene targeting approach and subsequently Aprt hetero-zygous and homozygous mice were derived. Aprt homozygous deficient animals were viable though the mendelian inheritance pattern was skewed. On average...

Topics

Adenine Phosphoribosyltransferase
Alleles
Animals
Base Sequence
Cell Line
DNA Primers
Gene Targeting
Heterozygote
Homozygote
Hypoxanthine Phosphoribosyltransferase
In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Mice

Mice, Knockout

Mice, Mutant Strains

Phenotype

Polymerase Chain Reaction

Source

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Identifiers

PMID: 9776749
DOI: 10.1093/nar/26.21.4888
PMCID: PMC147942

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