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Article

The spectra of large second-step mutations are similar for two different mouse autosomes.

Mutation research - 1 Jan 2008

Kasameyer Elizabeth, Connolly Lanelle, Lasarev Michael, Turker Mitchell S

Abstract excerpt

Loss of tumor suppressor gene expression via mutations plays a critical role in cancer development, particularly when occurring in heterozygous cells. These so-called "second-step" mutational events are often large in size and arise most often from chromosome loss, mitotic recombination, or interstitial deletion. An open question in cancer research is whether different chromosomes are equally susceptible to...

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Identifiers

PMID: 17714739
DOI: 10.1016/j.mrfmmm.2007.07.001
PMCID: PMC2233933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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