Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.

doi:10.1159/000134486

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Article

Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.

Cytogenetics and cell genetics - 1 Jan 1996

Shao C, Gupta P K, Sun Y, Sahota A, Tischfield J A

Abstract excerpt

Loss of the wild-type allele of a tumor suppressor gene, or loss of heterozygosity (LOH), is one of the most important mechanisms of carcinogenesis. Adenine phosphoribosyltransferase (APRT) has been used as a surrogate marker for tumor suppressor genes. We have previously shown that APRT deficien...

Topics

Adenine Phosphoribosyltransferase
Alleles
Aneuploidy
Cell Line
Cell Size
Chromosomes, Human, Pair 16
Clone Cells
Cosmids
Diploidy
Evolution, Molecular
Gene Deletion
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

In Situ Hybridization, Fluorescence

Microsatellite Repeats

Models, Genetic

Polyploidy

Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 9067427
DOI: 10.1159/000134486

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9067427-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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