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Article

Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.

Cytogenetics and cell genetics - 1 Jan 1996

Shao C, Gupta P K, Sun Y, Sahota A, Tischfield J A

Abstract excerpt

Loss of the wild-type allele of a tumor suppressor gene, or loss of heterozygosity (LOH), is one of the most important mechanisms of carcinogenesis. Adenine phosphoribosyltransferase (APRT) has been used as a surrogate marker for tumor suppressor genes. We have previously shown that APRT deficiency in an APRT heterozygous human cell line, MR12-1, was predominantly caused by the loss of the remaining wild-type...

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Source

Identifiers

PMID: 9067427
DOI: 10.1159/000134486

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.PMID 9067427Read ↗

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