Article
A comparison of approaches to account for uncertainty in analysis of imputed genotypes.
Genetic epidemiology - 1 Feb 2011
Zheng Jin, Li Yun, Abecasis Gonçalo R, Scheet Paul
Abstract excerpt
The availability of extensively genotyped reference samples, such as "The HapMap" and 1,000 Genomes Project reference panels, together with advances in statistical methodology, have allowed for the imputation of genotypes at single nucleotide polymorphism (SNP) markers that are untyped in a cohort or case-control study. These imputation procedures facilitate the interpretation and meta-analyses of genome-wide...
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