Article
Imputation of missing genotypes: an empirical evaluation of IMPUTE.
BMC genetics - 12 Dec 2008
Zhao Zhenming, Timofeev Nadia, Hartley Stephen W, Chui David Hk, Fucharoen Supan, Perls Thomas T, Steinberg Martin H, Baldwin Clinton T, Sebastiani Paola
Abstract excerpt
BACKGROUND: Imputation of missing genotypes is becoming a very popular solution for synchronizing genotype data collected with different microarray platforms but the effect of ethnic background, subject ascertainment, and amount of missing data on the accuracy of imputation are not well understood. RESULTS: We evaluated the accuracy of the program IMPUTE to generate the genotype data of partially or fully untyped...
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