Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimal methods for using posterior probabilities in association testing.

Human heredity - 1 Jan 2013

Liu Keli, Luedtke Alexander, Tintle Nathan

Abstract excerpt

OBJECTIVE: The use of haplotypes to impute the genotypes of unmeasured single nucleotide variants continues to rise in popularity. Simulation results suggest that the use of the dosage as a one-dimensional summary statistic of imputation posterior probabilities may be optimal both in terms of statistical power and computational efficiency; however, little theoretical understanding is available to explain and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome-Wide Association Study
Share to Genotype
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Data Interpretation, Statistical

Share to Probability

Source

Open in PubMed Open full text

Identifiers

PMID: 23548776
DOI: 10.1159/000349974
PMCID: PMC3706784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimal methods for using posterior probabilities in association testing.PMID 23548776Read ↗

Association studies with imputed variants using expectation-maximization likelihood-ratio tests.Semantic proximity Read ↗

Efficient approaches for large-scale GWAS with genotype uncertainty.Semantic proximity Read ↗

A comparison of approaches to account for uncertainty in analysis of imputed genotypes.Semantic proximity Read ↗

Comparison of multiple imputation and other methods for the analysis of imputed genotypes.Semantic proximity Read ↗

Optimum study design for detecting imprinting and maternal effects based on partial likelihood.Semantic proximity Read ↗

A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs.Semantic proximity Read ↗

Interaction association analysis of imputed SNPs in case-control and follow-up studies.Semantic proximity Read ↗

Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Semantic proximity Read ↗

Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies.Semantic proximity Read ↗

A POWERFUL METHOD FOR INCLUDING GENOTYPE UNCERTAINTY IN TESTS OF HARDY-WEINBERG EQUILIBRIUM.Semantic proximity Read ↗

Asymptotically exact fit for linear mixed model in genetic association studies.Semantic proximity Read ↗

Simple and efficient analysis of disease association with missing genotype data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.