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Article

Genotype-imputation accuracy across worldwide human populations.

American journal of human genetics - 1 Feb 2009

Huang Lucy, Li Yun, Singleton Andrew B, Hardy John A, Abecasis Gonçalo, Rosenberg Noah A, Scheet Paul

Abstract excerpt

A current approach to mapping complex-disease-susceptibility loci in genome-wide association (GWA) studies involves leveraging the information in a reference database of dense genotype data. By modeling the patterns of linkage disequilibrium in a reference panel, genotypes not directly measured in the study samples can be imputed and tested for disease association. This imputation strategy has been successful for...

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Identifiers

PMID: 19215730
DOI: 10.1016/j.ajhg.2009.01.013
PMCID: PMC2668016

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