Article
The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification.
Behavior genetics - 1 May 2013
Minică Camelia C, Dolan Conor V, Hottenga Jouke-Jan, Willemsen Gonneke, Vink Jacqueline M, Boomsma Dorret I
Abstract excerpt
When phenotypic, but no genotypic data are available for relatives of participants in genetic association studies, previous research has shown that family-based imputed genotypes can boost the statistical power when included in such studies. Here, using simulations, we compared the performance of two statistical approaches suitable to model imputed genotype data: the mixture approach, which involves the full...
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