Association studies with imputed variants using expectation-maximization likelihood-ratio tests.

Abstract excerpt

Genotype imputation has become standard practice in modern genetic studies. As sequencing-based reference panels continue to grow, increasingly more markers are being well or better imputed but at the same time, even more markers with relatively low minor allele frequency are being imputed with low imputation quality. Here, we propose new methods that incorporate imputation uncertainty for downstream association...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to MAF gene
• Share to Genetic Association Studies