Article
A POWERFUL METHOD FOR INCLUDING GENOTYPE UNCERTAINTY IN TESTS OF HARDY-WEINBERG EQUILIBRIUM.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2017
Beck Andrew, Luedtke Alexander, Liu Keli, Tintle Nathan
Abstract excerpt
The use of posterior probabilities to summarize genotype uncertainty is pervasive across genotype, sequencing and imputation platforms. Prior work in many contexts has shown the utility of incorporating genotype uncertainty (posterior probabilities) in downstream statistical tests. Typical approaches to incorporating genotype uncertainty when testing Hardy-Weinberg equilibrium tend to lack calibration in the type...
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