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Article

The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function.

World journal of surgery - 1 Aug 2011

Zhou Guisheng, Gingras Marie-Claude, Liu Shi-He, Li Donghui, Li Zhijun, Catania Robbi L, Stehling Kelly M, Li Min, Paganelli Giovanni, Gibbs Richard A, Demayo Francesco J, Fisher William E, Brunicardi F Charles

Abstract excerpt

BACKGROUND: Somatostatin receptor subtype 5 (SSTR5) mediates the inhibitory effect of somatostatin on insulin expression/secretion and cell proliferation. A number of single nucleotide polymorphisms (SNPs) of SSTR5 have been identified, including P335L, a nonsynonymous SNP located in the protein C-terminal region and encrypted by the codon CCG (proline) or the codon CTG (leucine). In the present study we sought...

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Source

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Identifiers

PMID: 21249361
DOI: 10.1007/s00268-010-0939-9
PMCID: PMC4137969

Genes

SSTR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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