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Article

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway.

The EMBO journal - 6 Sept 2006

Bousquet Corinne, Guillermet-Guibert Julie, Saint-Laurent Nathalie, Archer-Lahlou Elodie, Lopez Frédéric, Fanjul Marjorie, Ferrand Audrey, Fourmy Daniel, Pichereaux Carole, Monsarrat Bernard, Pradayrol Lucien, Estève Jean-Pierre, Susini Christiane

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) regulates many cellular functions including growth and survival, and its excessive activation is a hallmark of cancer. Somatostatin, acting through its G protein-coupled receptor (GPCR) sst2, has potent proapoptotic and anti-invasive activities on normal and cancer cells. Here, we report a novel mechanism for inhibiting PI3K activity. Somatostatin, acting through sst2,...

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Identifiers

PMID: 16917505
DOI: 10.1038/sj.emboj.7601279
PMCID: PMC1560358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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