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Article

FGFR4 polymorphic alleles modulate mitochondrial respiration: A novel target for somatostatin analog action in pituitary tumors.

Oncotarget - 10 Jan 2017

Ezzat Shereen, Wang Ri, Pintilie Melania, Asa Sylvia L

Abstract excerpt

We reported that a single nucleotide polymorphism (SNP) at codon 388 of the fibroblast growth factor receptor 4 (FGFR4-Gly388Arg) can result in distinct proteins that alter pituitary cell growth and function. Here, we examined the differential properties of the available therapeutic somatostatin analogs, octreotide and pasireotide, in pituitary tumor cells expressing the different FGFR4 isoforms. Consistent with...

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Share to Antineoplastic Agents, Hormonal
Share to Cell Respiration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pituitary Neoplasms

Share to Protein Transport

Share to Receptor, Fibroblast Growth Factor, Type 4

Share to Somatostatin

Share to STAT3 Transcription Factor

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 27966451
DOI: 10.18632/oncotarget.13843
PMCID: PMC5356897

Genes

FGFR4
STAT3
SSTR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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