Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.

doi:10.1210/me.2012-1095

Article

Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2012

Zhou Guisheng, Liu Shi-He, Shahi Kelly M, Wang Hua, Duan Xueyan, Lin Xia, Feng Xin-Hua, Li Min, Fisher William E, Demayo Francesco J, Dawson David, Brunicardi F Charles

Abstract excerpt

Somatostatin receptor subtype 5 (SSTR5) mediates the inhibitory effect of somatostatin and its analogs on insulin expression/secretion and islet cell proliferation. We provide biochemical and genetic evidence that SSTR5 exerted its physiological actions via down-regulating pancreatic and duodenal homeobox-1 (PDX-1), a β-cell-specific homeodomain-containing transcription factor. Cotransfection of SSTR5 with PDX-1...

Topics

Animals
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Glucagon-Like Peptide 1
Glucose
HEK293 Cells
Homeodomain Proteins
Humans
Insulin

Insulin Secretion

Insulinoma

Mice

Mice, Knockout

Polymorphism, Single Nucleotide

Proliferating Cell Nuclear Antigen

RNA Interference

RNA, Messenger

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.