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Article

Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2012

Zhou Guisheng, Liu Shi-He, Shahi Kelly M, Wang Hua, Duan Xueyan, Lin Xia, Feng Xin-Hua, Li Min, Fisher William E, Demayo Francesco J, Dawson David, Brunicardi F Charles

Abstract excerpt

Somatostatin receptor subtype 5 (SSTR5) mediates the inhibitory effect of somatostatin and its analogs on insulin expression/secretion and islet cell proliferation. We provide biochemical and genetic evidence that SSTR5 exerted its physiological actions via down-regulating pancreatic and duodenal homeobox-1 (PDX-1), a β-cell-specific homeodomain-containing transcription factor. Cotransfection of SSTR5 with PDX-1...

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Source

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Identifiers

PMID: 22669743
DOI: 10.1210/me.2012-1095
PMCID: PMC3385795

Genes

SSTR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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