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Article

Genetic polymorphisms in human proton-dependent dipeptide transporter PEPT1: implications for the functional role of Pro586.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2004

Zhang Eric Y, Fu Dong-Jing, Pak Youngeen A, Stewart Trent, Mukhopadhyay Nitai, Wrighton Steven A, Hillgren Kathleen M

Abstract excerpt

The human proton-dependent dipeptide transporter (PEPT1, gene SLC15A1) is important for intestinal absorption of di- and tripeptides and a variety of peptidomimetic compounds. Using a DNA polymorphism discovery panel of 44 ethnically diverse individuals, nine nonsynonymous and four synonymous coding-region single-nucleotide polymorphisms (SNPs) were identified in PEPT1. HeLa cells were transiently transfected...

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Identifiers

PMID: 15075386
DOI: 10.1124/jpet.104.065912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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