Article
Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.
European journal of endocrinology - 1 Oct 2011
Ciganoka Darja, Balcere Inga, Kapa Ivo, Peculis Raitis, Valtere Andra, Nikitina-Zake Liene, Lase Ieva, Schiöth Helgi B, Pirags Valdis, Klovins Janis
Abstract excerpt
OBJECTIVE: The aim of this study was to characterize the genetic variance of somatostatin receptor 5 (SSTR5) and investigate the possible correlation of such variants with acromegaly risk and different disease characteristics. DESIGN AND METHODS: The SSTR5 gene coding region and 2000 bp upstream region was sequenced in 48 patients with acromegaly and 96 control subjects. Further, three single nucleotide...
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