Article
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Cancer cell - 17 Mar 2014
Klco Jeffery M, Spencer David H, Miller Christopher A, Griffith Malachi, Lamprecht Tamara L, O'Laughlin Michelle, Fronick Catrina, Magrini Vincent, Demeter Ryan T, Fulton Robert S, Eades William C, Link Daniel C, Graubert Timothy A, Walter Matthew J, Mardis Elaine R, Dipersio John F, Wilson Richard K, Ley Timothy J
Abstract excerpt
The relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole-genome sequencing using a variety of experimental approaches. We found that virtually all AML subclones trafficked from the marrow to the peripheral blood, but some were enriched in specific cell populations....
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