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Article

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary Perspective

16 Dec 2021

Abstract excerpt

Clonal evolution represents the natural process through which cancer cells continuously search for phenotypic advantages that enable them to develop and expand within microenvironmental constraints. In chronic lymphocytic leukemia (CLL), clonal evolution underpins leukemic progression and therapeutic resistance, with differences in clonal evolutionary dynamics accounting for its characteristically diverse...

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PMID: 34976831
DOI: 10.3389/fonc.2021.790004

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