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Article

Clonal evolution and tumor-initiating cells: New dimensions in cancer patient treatment.

Critical reviews in clinical laboratory sciences - 1 Jan 2016

Apostoli Anthony J, Ailles Laurie

Abstract excerpt

Human cancer is not a uniform disease but a plethora of disparate tumor types and subtypes. The differences that exist between individual tumors (intertumoral heterogeneity) present a significant roadblock to the eradication of cancer. It has also become increasingly clear that variations across individual tumors (intratumoral heterogeneity) have important implications to cancer progression and treatment...

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Identifiers

PMID: 26397062
DOI: 10.3109/10408363.2015.1083944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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