Article
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.
Nature communications - 14 Feb 2020
Zhuang Youwen, Liu Heng, Edward Zhou X, Kumar Verma Ravi, de Waal Parker W, Jang Wonjo, Xu Ting-Hai, Wang Lei, Meng Xing, Zhao Gongpu, Kang Yanyong, Melcher Karsten, Fan Hao, Lambert Nevin A, Eric Xu H, Zhang Cheng
Abstract excerpt
Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligands with a large chemical diversity generated at different stages of inflammation to either promote or resolve inflammation in order to maintain a balanced...
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