Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages.

doi:10.1128/JVI.66.5.2698-2708.1992

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Article

Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages.

Journal of virology - 1 May 1992

Farina S F, Huff J L, Parsons J T

Abstract excerpt

Avian myelocytomatosis virus MC29 induces a wide variety of neoplastic diseases in infected birds and transforms cells of the macrophage lineage as well as fibroblasts and epithelial cells. A biological and biochemical analysis, carried out on a series of in-frame insertion and deletion mutations within the gag-myc gene of MC29, revealed several mutations within the 5' portion of the v-myc gene that encode...

Topics

Animals
Avian Leukosis Virus
Cell Transformation, Viral
Cells, Cultured
Chick Embryo
Cloning, Molecular
DNA Mutational Analysis
Fibroblasts
Fusion Proteins, gag-onc
Genes, myc
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Vectors

Macrophages

Mutation

Oncogene Protein p55(v-myc)

Phenotype

Transcription, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1313895
DOI: 10.1128/JVI.66.5.2698-2708.1992
PMCID: PMC241024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1313895-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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