Article
The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.
Biological psychiatry - 15 Apr 2011
Juhasz Gabriella, Dunham Jason S, McKie Shane, Thomas Emma, Downey Darragh, Chase Diana, Lloyd-Williams Kathryn, Toth Zoltan G, Platt Hazel, Mekli Krisztina, Payton Antony, Elliott Rebecca, Williams Steve R, Anderson Ian M, Deakin J F William
Abstract excerpt
BACKGROUND: The neuroplastic pathway, which includes cyclic adenosine monophosphate response element-binding protein 1 (CREB1), brain-derived neurotrophic factor (BDNF), and its receptor (neurotrophic tyrosine kinase receptor, type 2 [NTRK2]), plays a crucial role in the adaptation of brain to stress, and thus variations of these genes are plausible risk factors for depression. METHODS: A population-based sample...
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