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Article

Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder.

Biological psychiatry - 15 Oct 2012

Murphy Melissa L, Carballedo Angela, Fagan Andrew J, Morris Derek, Fahey Ciara, Meaney James, Frodl Thomas

Abstract excerpt

BACKGROUND: Polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and its receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) have been implicated in mood disorders. The aim of this study was to examine whether the NTRK2 and BDNF polymorphisms impact brain white matter connections in major depressive disorder and whether they may also have an interactive effect with environmental stress in...

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Source

Identifiers

PMID: 22609366
DOI: 10.1016/j.biopsych.2012.04.015

Genes

NTRK2
BDNF

Provenance

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