Article
A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females.
Translational psychiatry - 13 Dec 2011
Klok M D, Giltay E J, Van der Does A J W, Geleijnse J M, Antypa N, Penninx B W J H, de Geus E J C, Willemsen G, Boomsma D I, van Leeuwen N, Zitman F G, de Kloet E R, DeRijk R H
Abstract excerpt
Mineralocorticoid (MR) and glucocorticoid receptors (GR) are abundantly expressed in the limbic brain and mediate cortisol effects on the stress-response and behavioral adaptation. Dysregulation of the stress response impairs adaptation and is a risk factor for depression, which is twice as abundant in women than in men. Because of the importance of MR for appraisal processes underlying the initial phase of the...
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