Article
Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression.
Biological psychiatry - 1 Nov 2010
Gatt Justine M, Nemeroff Charles B, Schofield Peter R, Paul Robert H, Clark C Richard, Gordon Evian, Williams Leanne M
Abstract excerpt
BACKGROUND: Depression will be the second largest burden of disease by 2020. Developing new tools for identifying risk and ultimately prevention of depression relies on elucidating the integrative relationships between susceptibility markers from gene-stress interactions and how they impact emotional brain and arousal systems. They have largely been studied in isolation. METHODS: We examined how genetic...
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