Article
Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder.
JAMA psychiatry - 1 Feb 2014
Peterson Bradley S, Wang Zhishun, Horga Guillermo, Warner Virginia, Rutherford Bret, Klahr Kristin W, Graniello Barbara, Wickramaratne Priya, Garcia Felix, Yu Shan, Hao Xuejun, Adams Phillip B, Qian Ming, Liu Jun, Gerber Andrew, Weissman Myrna M
Abstract excerpt
IMPORTANCE: The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons who have either a high or low familial risk for depression. OBJECTIVE: To distinguish risk and resilience...
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