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Article

Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia.

Biological psychiatry - 15 Sept 2006

Winterer Georg, Egan Michael F, Kolachana Bhaskar S, Goldberg Terry E, Coppola Richard, Weinberger Daniel R

Abstract excerpt

BACKGROUND: Increased variability of stimulus-induced prefrontal electromagnetic activity ("noise") has been associated with genetic risk for schizophrenia. On the basis of animal experiments and computational models, we have predicted that this prefrontal "noise" phenotype would be related to variation in prefrontal dopamine (DA) signaling, which itself might be abnormal in schizophrenia. In the present study,...

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Source

Identifiers

PMID: 16730334
DOI: 10.1016/j.biopsych.2006.03.023

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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