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Article

Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2007

Tan Hao-Yang, Chen Qiang, Sust Steven, Buckholtz Joshua W, Meyers John D, Egan Michael F, Mattay Venkata S, Meyer-Lindenberg Andreas, Weinberger Daniel R, Callicott Joseph H

Abstract excerpt

Dopaminergic and glutamatergic systems are critical components responsible for prefrontal signal-to-noise tuning in working memory. Recent functional MRI (fMRI) studies of genetic variation in these systems in catechol-O-methyltransferase (COMT) and in metabotropic glutamate receptor mgluR3 (GRM3), respectively, suggest that these genes influence prefrontal physiological signal-to-noise in humans. Here, using...

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Source

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Identifiers

PMID: 17636131
DOI: 10.1073/pnas.0610125104
PMCID: PMC1920538

Genes

COMT
GRM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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