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Article

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling.

Frontiers in immunology - 1 Jan 2026

Reyes-Reyes Elsa M, Chinnasamy Dhanalakshmi, Trial Michael D, Fernandez Fernando, Nguyen Vincent D, He Qianying, Leslie Angel-Grace, Begay Jessica, Triplett Jessica, Bradford David, Figueroa Carolina, Wiegand Jean P, Rodgers Kathleen E

Abstract excerpt

Introduction: The major histocompatibility complex class II (MHC-II) pathway is central to adaptive immunity and immune tolerance, and its age-related dysregulation is increasingly linked to chronic neuroinflammation. The HLA-DRB1*15:01 allele, the strongest genetic risk factor for multiple sclerosis, has been implicated in shaping pathogenic CD4+ T-cell responses and broader neuroimmune vulnerability, yet how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42382783
DOI: 10.3389/fimmu.2026.1796692
PMCID: PMC13314512

Genes

CD4
CD14
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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