Article

LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

2017-11-16

Abstract excerpt

Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biologi...

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Literature Corpus work: 424a83e1-59be-5b8d-af45-482ac9e64a27
DOI: 10.12688/f1000research.12169.1

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