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Article

Essential functions of the histone demethylase lid.

PLoS genetics - 24 Nov 2010

Li Ling, Greer Christina, Eisenman Robert N, Secombe Julie

Abstract excerpt

Drosophila Little imaginal discs (Lid) is a recently described member of the JmjC domain class of histone demethylases that specifically targets trimethylated histone H3 lysine 4 (H3K4me3). To understand its biological function, we have utilized a series of Lid deletions and point mutations to assess the role that each domain plays in histone demethylation, in animal viability, and in cell growth mediated by the...

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Identifiers

PMID: 21124823
DOI: 10.1371/journal.pgen.1001221
PMCID: PMC2991268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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