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BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels

2023-03-28

Abstract excerpt

Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modifications likely contributes to disease states and cancer. Depletion of the chromatin-binding protein BRWD3, a known substrate-specificity factor of the Cul4-DDB1 E3 ubiquitin ligase complex, results in increased in H3K4me1 levels. The underlying mechanism linking BRWD3 and H3K4 methylation, howe...

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Literature Corpus work
8ac5aad2-9b6c-52c3-b978-4e4beafc4e48
DOI
10.1101/2023.03.28.534572
Open publication

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BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levelsDOI 10.1101/2023.03.28.534572
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