Article
Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis.
PloS one - 22 Dec 2010
Timmermann Bernd, Kerick Martin, Roehr Christina, Fischer Axel, Isau Melanie, Boerno Stefan T, Wunderlich Andrea, Barmeyer Christian, Seemann Petra, Koenig Jana, Lappe Michael, Kuss Andreas W, Garshasbi Masoud, Bertram Lars, Trappe Kathrin, Werber Martin, Herrmann Bernhard G, Zatloukal Kurt, Lehrach Hans, Schweiger Michal R
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is with approximately 1 million cases the third most common cancer worldwide. Extensive research is ongoing to decipher the underlying genetic patterns with the hope to improve early cancer diagnosis and treatment. In this direction, the recent progress in next generation sequencing technologies has revolutionized the field of cancer genomics. However, one caveat of these...
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