Article
Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer.
Cancer research - 1 Aug 2017
Kondelin Johanna, Gylfe Alexandra E, Lundgren Sofie, Tanskanen Tomas, Hamberg Jiri, Aavikko Mervi, Palin Kimmo, Ristolainen Heikki, Katainen Riku, Kaasinen Eevi, Taipale Minna, Taipale Jussi, Renkonen-Sinisalo Laura, Järvinen Heikki, Böhm Jan, Mecklin Jukka-Pekka, Vahteristo Pia, Tuupanen Sari, Aaltonen Lauri A, Pitkänen Esa
Abstract excerpt
Approximately 15% of colorectal cancers exhibit microsatellite instability (MSI), which leads to accumulation of large numbers of small insertions and deletions (indels). Genes that provide growth advantage to cells via loss-of-function mutations in microsatellites are called MSI target genes. Several criteria to define these genes have been suggested, one of them being simple mutation frequency. Microsatellite...
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