Article
Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation.
Genome biology - 6 Aug 2024
Jonchère Vincent, Montémont Hugo, Le Scanf Enora, Siret Aurélie, Letourneur Quentin, Tubacher Emmanuel, Battail Christophe, Fall Assane, Labreche Karim, Renault Victor, Ratovomanana Toky, Buhard Olivier, Jolly Ariane, Le Rouzic Philippe, Feys Cody, Despras Emmanuelle, Zouali Habib, Nicolle Rémy, Cervera Pascale, Svrcek Magali, Bourgoin Pierre, Blanché Hélène, Boland Anne, Lefèvre Jérémie, Parc Yann, Touat Mehdi, Bielle Franck, Arzur Danielle, Cueff Gwennina, Le Jossic-Corcos Catherine, Quéré Gaël, Dujardin Gwendal, Blondel Marc, Le Maréchal Cédric, Cohen Romain, André Thierry, Coulet Florence, de la Grange Pierre, de Reyniès Aurélien, Fléjou Jean-François, Renaud Florence, Alentorn Agusti, Corcos Laurent, Deleuze Jean-François, Collura Ada, Duval Alex
Abstract excerpt
BACKGROUND: Microsatellite instability (MSI) due to mismatch repair deficiency (dMMR) is common in colorectal cancer (CRC). These cancers are associated with somatic coding events, but the noncoding pathophysiological impact of this genomic instability is yet poorly understood. Here, we perform an analysis of coding and noncoding MSI events at the different steps of colorectal tumorigenesis using whole exome...
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