Article
Identification of the Lynch syndrome and Lynch-like syndrome specific somatic mutations in microsatellite instability-high colorectal cancer cases.
Surgery today - 1 Jul 2026
Ofuchi Takashi, Hirose Kosuke, Hosoda Kiyotaka, Ikehara Tomohiko, Higuchi Satoshi, Tsujimoto Akinori, Wada Aoi, Tamaoka Yuta, Tsuda Yasuo, Otsu Hajime, Yonemura Yusuke, Iwatsuki Masaaki, Mimori Koshi
Abstract excerpt
PURPOSE: Lynch syndrome (LS), the most common hereditary colorectal cancer (CRC), is caused by germline mutations in mismatch repair (MMR) genes, resulting in microsatellite instability-high (MSI-H) tumors. Lynch-like syndrome (LL) exhibits MSI-H and MMR deficiency, but lacks identifiable germline MMR mutations. Although LS/LL CRCs share clinical and molecular features, they are distinct from sporadic MSI-H (SM)...
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