Article

Molecular Characterization of Sporadic Colorectal Cancer: Association Between KRAS, NRAS, and BRAF Mutations and Microsatellite Instability via Next-Generation Sequencing

2025-05-20

Abstract excerpt

We retrospectively and cross-sectionally reviewed 648 cases with histological diagnosis of colon adenocarcinoma. Of these, 166 had partial molecular studies, and 42 cases were selected based on the availability of the genetic markers targeted in this study. We analyzed the frequency of mutations in these genes, as well as their correlation with microsatellite instability (MSI). A high mutation rate was found in KR...

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Literature Corpus work: 2027897e-1949-53e0-9610-7c663267bed8
DOI: 10.20944/preprints202505.1617.v1

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